Risk Groups

PORTEC and GOG risk group definitions.

Reference criteria used by the Stage I Endometrial Cancer Calculator.

PORTEC Risk Groups GOG Risk Groups References
PORTEC

PORTEC Risk Groups and Inclusion/Exclusion Criteria

View PORTEC references

PORTEC-based risk group Criteria
Low risk Any age, Stage IA, grade 1
Age < 60, Stage IA, grade 1 or 2
Low-intermediate risk Any age, Stage IA, grade 2
Age < 60, Stage IA, grade 3 or 4
Age < 60, Stage IB, grade 1 or 2
High-intermediate risk Age >= 60, Stage IA, grade 3 or 4
Age >= 60, Stage IB, grade 1 or 2
High risk Any age, Stage IB, grade 3 or 4

Note: Grade 1, well-differentiated; Grade 2, moderately-differentiated; Grade 3, poorly-differentiated; Grade 4, undifferentiated; PORTEC, Post-Operative Radiation Therapy in Endometrial Cancer. For the purpose of this calculator, Grade 3 includes Grade 3 or 4.

PORTEC2 Inclusion and Exclusion Criteria

Inclusion Criteria
  • Age > 60 years and Stage IB Grade 1 or 2 disease, or stage IA Grade 3 disease
  • Stage I disease with endocervical glandular involvement, any age, except for Grade 3 with > 50% myometrial invasion
  • Stage IB Grade 3 disease was not allowed on study
  • WHO performance score of 0-2
Exclusion Criteria
  • Serous or clear cell carcinoma
  • Staging lymphadenectomy
  • Interval between surgery and radiotherapy more than 8 weeks
  • History of previous malignant disease
  • Previous radiotherapy, hormonal therapy, or chemotherapy
  • Previous diagnosis of Crohn's disease or ulcerative colitis
GOG99

Adapted GOG99 Risk Groups and Inclusion/Exclusion Criteria

View GOG references

GOG99 pathologic risk factors include grade 2 or 3, outer third myometrial invasion, and lymphovascular invasion.

Adapted GOG99 risk group Criteria
Low risk Any age, Stage IA, grade 1 or 2, no LVSI
Low-intermediate risk Any age, Stage IB, any grade but not meeting high-intermediate criteria
High-intermediate risk Age >= 70 and at least 1 pathologic risk factor
Age >= 50 and at least 2 pathologic risk factors
Any age and all 3 pathologic risk factors
High risk Stage III or IV

Note: Pathologic risk factors include grade 2 or 3, outer third myometrial invasion, and lymphovascular invasion. Increasing age is also a risk factor. These factors were associated with an increased recurrence rate based on analysis of historical data from GOG33.

GOG99 Inclusion Criteria

  • Required TAH/BSO, selective bilateral pelvic and para-aortic lymphadenectomy with removal of any enlarged or suspicious nodes
  • Lymph node assessment was mandatory
  • WBC, platelets, creatinine, bilirubin, and SGOT blood work parameters
  • GOG performance status < 2
  • Normal chest X-ray
  • Negative peritoneal cytology
  • No history of another cancer except skin, excluding melanoma
  • No history of radiation therapy
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